A growing body of recent evidence indicate that neurotrophins can act as mediators of neuronal plasticity. In the context of a more detailed, comprehensive understanding of the function of neurotrophins it is essential to characterize where neurotrophins are synthesised and stored and from where they are released. Here we present evidence that the mRNAs for NGF, trkB and BDNF but not trkA are localised in the dendrites of rat neurons, thus implying that neurotrophins and their receptors can be synthesised at locations close to their sites of function, with particular regard to the dendritic synapses. The significance of this finding and its possible implications for synaptic plasticity are discussed within the theoretical framework of the synapse-specific control of individual synapses of a given neuron.
Subcellular localisation of neurotrophins and neurotrophin receptors: implications for synaptic plasticity
CATTANEO, ANTONINO
1996
Abstract
A growing body of recent evidence indicate that neurotrophins can act as mediators of neuronal plasticity. In the context of a more detailed, comprehensive understanding of the function of neurotrophins it is essential to characterize where neurotrophins are synthesised and stored and from where they are released. Here we present evidence that the mRNAs for NGF, trkB and BDNF but not trkA are localised in the dendrites of rat neurons, thus implying that neurotrophins and their receptors can be synthesised at locations close to their sites of function, with particular regard to the dendritic synapses. The significance of this finding and its possible implications for synaptic plasticity are discussed within the theoretical framework of the synapse-specific control of individual synapses of a given neuron.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
