本发明涉及一种溶液，其包含：在由水/有机溶剂混合物或有机溶剂组成的溶剂中的杂多酸和镧系元素盐。任选地，该溶液还可以包含具有包括在4‑6的区间内的pH的有机缓冲液或无机缓冲液，或强碱或强酸。本发明的目的还包括所述溶液及其组分之间的反应的任何产物作为用于生物样品的造影介质的用途，以及用于制备生物样品的方法，该方法在至少一个步骤中使用所述溶液用于通过关联显微术(CLEM)和电子显微术(EM)进行分析。
The invention relates to a solution comprising: a heteropolyacid and a lanthanide salt in a solvent consisting of a water/organic solvent mixture or an organic solvent. Optionally, the solution can also comprise an organic or inorganic buffer with a pH comprised in the interval of 4-6 or a strong base or acid. The object of the present invention also includes a use of said solution and any products of the reaction between the components thereof as a contrast medium for biological samples and a method for preparing biological samples that uses said solution in at least one step, for analysis by either correlative microscopy (CLEM) and electron microscopy (EM).
用于由电子显微术或关联显微术表征生物样品的造影溶液
SIGNORE GIOVANNI
2020
Abstract
The invention relates to a solution comprising: a heteropolyacid and a lanthanide salt in a solvent consisting of a water/organic solvent mixture or an organic solvent. Optionally, the solution can also comprise an organic or inorganic buffer with a pH comprised in the interval of 4-6 or a strong base or acid. The object of the present invention also includes a use of said solution and any products of the reaction between the components thereof as a contrast medium for biological samples and a method for preparing biological samples that uses said solution in at least one step, for analysis by either correlative microscopy (CLEM) and electron microscopy (EM).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
