The present invention relates to the process of preparing multicomponent lipidic nanoparticles (LNP) with high cellular fusogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also relates to the nanoparticles thus obtained. In particular, the lipidic nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio to each other to be administered both subcutaneously (intradermally or intramuscularly) and systemically with fewer side effects than the lipidic nanoparticles known in the art.
MULTICOMPONENT LIPID NANOPARTICLES WITH HIGH CELLULAR FUSOGENICITY FOR THE DELIVERY OF NUCLEIC ACIDS AND RELATED PREPARATION PROCESS
CARDARELLI Francesco;CARACCIOLO Giulio
2023
Abstract
The present invention relates to the process of preparing multicomponent lipidic nanoparticles (LNP) with high cellular fusogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also relates to the nanoparticles thus obtained. In particular, the lipidic nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio to each other to be administered both subcutaneously (intradermally or intramuscularly) and systemically with fewer side effects than the lipidic nanoparticles known in the art.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
