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Debunking Boyle's Self-Flowing Flask

This paper investigates the widespread myth of perpetual motion devices based on the so-called Boyle’s self-flowing flask, frequently popularized in online videos. A simplified theoretical model is developed to describe the dynamics of the system, showing that the flow inevitably decays and that the maximum operating time is only a few seconds for realistic geometries. Simple original tabletop experiments with hoses of different sizes confirm this picture, yielding even shorter operating time...

Book review: The Druze Emir in Renaissance Europe : Review of Gorton, Ted J., Renaissance Emir: A Druze Warlord at the Court of the Medici

This review critically examines the biography of Fakhr ad-Din Ma’n II, a Druze emir whose life spanned the complex geopolitical and cultural landscapes of the Early Modern Levant and Renaissance Europe. Gorton’s work offers a meticulously researched and accessible account of Fakhr ad-Din’s political career, exile in Tuscany, and enduring legacy, situating him within broader narratives of cross-cultural diplomacy, religious identity, and Mediterranean courtly culture. The review highlights the...

Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes

Leucine-rich repeat kinase 2 (LRRK2) not only plays a vital role in familial forms of Parkinson's disease (PD) but also represents a risk factor for idiopathic PD. Its multi-domain architecture enables fine-tuned regulation of its biological function by orchestrating intra- and inter-molecular interactions. Here, we present BioID proximity proteomes of LRRK2 that reveal new interactors, which we further characterize using a novel evolutionary and structural bioinformatics pipeline. Co-evoluti...

High-throughput screening for ageing and age-related disease drug discovery : advances and challenges

Ageing is the primary risk factor for many chronic, degenerative, and life-threatening disorders, yet the translational pipeline for geroprotective interventions remains comparatively sparse. Short‑lived, experimentally tractable models with conserved ageing pathways, particularly Caenorhabditis elegans , Drosophila melanogaster , and the African turquoise killifish (Nothobranchius furzeri), have expanded discovery beyond traditionally mammalian-centric pipelines. By leveraging advances in au...

Analysis of Different Strains of the Turquoise Killifish Identify Transcriptomic Signatures Associated with Heritable Lifespan Differences

The African turquoise killifish Nothobranchius furzeri represents an emerging short-lived vertebrate model for aging research. Captive strains of this species are characterized by large differences in lifespan. To identify gene expression correlates of this lifespan differences, we analyzed a public transcriptomic dataset comprising 4 different tissues in addition to embryos. We focused on the GRZ and the MZM0410 captive strains, which show a near twofold difference in lifespan, but similar g...

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