Today, public health is one of the most important challenges in society. Cancer is the leading cause of death, so early diagnosis and localized treatments that minimize side effects are a priority. Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents, detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition, they provide the particles with functional chemical groups that allow their bioconjugation. This work analyzes three types of self-assembled bilayer fatty acid coatings of superparamagnetic iron oxide nanoparticles: oleic, lauric, and myristic acids. We characterize the particles magnetically and structurally and study their potential for resonance imaging, magnetic hyperthermia, and labeling for biosensing in lateral flow immunoassays. We found that the myristic acid sample reported a large r2 relaxivity, superior to existing iron-based commercial agents. For magnetic hyperthermia, a significant specific absorption rate value was obtained for the oleic sample. Finally, the lauric acid sample showed promising results for nanolabeling.

Double-Layer Fatty Acid Nanoparticles as a Multiplatform for Diagnostics and Therapy

Guerrini, Andrea
Methodology
;
2022

Abstract

Today, public health is one of the most important challenges in society. Cancer is the leading cause of death, so early diagnosis and localized treatments that minimize side effects are a priority. Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents, detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition, they provide the particles with functional chemical groups that allow their bioconjugation. This work analyzes three types of self-assembled bilayer fatty acid coatings of superparamagnetic iron oxide nanoparticles: oleic, lauric, and myristic acids. We characterize the particles magnetically and structurally and study their potential for resonance imaging, magnetic hyperthermia, and labeling for biosensing in lateral flow immunoassays. We found that the myristic acid sample reported a large r2 relaxivity, superior to existing iron-based commercial agents. For magnetic hyperthermia, a significant specific absorption rate value was obtained for the oleic sample. Finally, the lauric acid sample showed promising results for nanolabeling.
2022
Settore FIS/03 - Fisica della Materia
Biosensor; Inductive sensing; Lateral flow immunoassays; Magnetic hyperthermia; Magnetic nanoparticles; Magnetic relaxation; Magnetic resonance imaging
   MAT2017-84959-C2-1-R
   the Spanish Ministry of Economy and Competitiveness

   MCI-20-EIN2020-112354
   the Spanish Ministry of Economy and Competitiveness

   FICYT/IDI/2021/000100
   the Principality of Asturias (Spain)

   FICYT/IDI/2021/000273
   the Principality of Asturias (Spain)

   RA-TB/CFATR/LMF multiannual research program 2021–2025
   Romanian Ministry of Research

   JNIR-RO grant 04-4-1142-2021/2025—item 34—JINR Order no. 365/11.05.2021
   Romanian Ministry of Research

   project Ferro-Tera
   the Romanian Academy and Italian National research Council

   “Severo Ochoa” fellowship
   Consejería de Educación y Cultura del Gobierno del Principado de Asturias

   grant CEI15-24
   University of Oviedo, the Ministry of Education, Culture and Sport, and Banco Santander

   grant SV-21-GIJON-03
   University Technological Institute of Asturias (IUTA)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11384/139543
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