We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [I-125]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET(A) antagonist BQ 123. A single class of ET(A) receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function.
|Titolo:||Characterization of endothelin(A) receptors in cerebral and peripheral arteries of rat|
|Data di pubblicazione:||1995|
|Appare nelle tipologie:||1.1 Articolo in rivista|