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EnglishWe have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [I-125]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET(A) antagonist BQ 123. A single class of ET(A) receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function.
| Titolo: | Characterization of endothelin(A) receptors in cerebral and peripheral arteries of rat |
| Autori: | |
| Data di pubblicazione: | 1995 |
| Rivista: | |
| Abstract: | We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [I-125]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET(A) antagonist BQ 123. A single class of ET(A) receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function. |
| Handle: | http://hdl.handle.net/11384/22984 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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