Existence of anticorrelations for local field potentials recorded from mice reared in standard condition and environmental enrichment

In the present paper, we analyze local field potentials (LFPs) recorded from the secondary motor cortex (M2) and primary visual cortex (V1) of freely moving mice reared in environmental enrichment (EE) and standard condition (SC). We focus on the scaling properties of the signals by using an integrated approach combining three different techniques: the Higuchi method, detrended fluctuation analysis, and power spectrum. Each technique provides direct or indirect estimations of the Hurst exponent H and this prevents spurious identification of scaling properties in time-series analysis. It is well known that the power spectrum of an LFP signal scales as 1/f(β) with β>0. Our results indicate the existence of a particular power spectrum scaling law 1/f(β) with β<0 for low frequencies (f<4 Hz) for both SC and EE rearing conditions. This type of scaling behavior is associated to the presence of anticorrelation in the corresponding LFP signals. Moreover, since EE is an experimental protocol based on the enhancement of sensorimotor stimulation, we study the possible effects of EE on the scaling properties of secondary motor cortex (M2) and primary visual cortex (V1). Notably, the difference between Hurst's exponents in EE and SC for individual cortical regions (M2) and (V1) is not statistically significant. On the other hand, using the detrended cross-correlation coefficient, we find that EE significantly reduces the functional coupling between secondary motor cortex (M2) and visual cortex (V1).