In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors

Malatesta, P; Sgado, P; Caneparo, L; Barsacchi, G; Cremisi, Federico

doi:10.1016/S0165-3806(01)00170-5

The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.

Titolo:	In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors
Autori:	MALATESTA P SGADO P CANEPARO L BARSACCHI G CREMISI, Federico mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2001
Rivista:	BRAIN RESEARCH
Abstract:	The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.
Handle:	http://hdl.handle.net/11384/7100
Appare nelle tipologie:	1.1 Articolo in rivista

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