The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.
In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors
CREMISI, Federico
2001
Abstract
The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Malatesta et al. - 2001 - In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors.pdf
Accesso chiuso
Tipologia:
Altro materiale allegato
Licenza:
Tutti i diritti riservati
Dimensione
467.28 kB
Formato
Adobe PDF
|
467.28 kB | Adobe PDF | Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
