The PC3 gene is a marker of dividing neuroepithelial (NE) cells. We transduced single cortical precursors of the ventricular zone (VZ) with a PC3-carrying retroviral vector at E16 stage, and analysed the effects of transgene expression on their progeny in 3-week-old animals. Unlike control-transduced cells, all viable PC3-transduced cells remained close to the ventricle and displayed a round-shaped, undifferentiated morphology.
Titolo: | In vivo PC3 overexpression by retroviral vector affects cell differentiation of rat cortical precursors |
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Data di pubblicazione: | 2001 |
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Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0165-3806(01)00170-5 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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