We describe here the function and structure of the precursor of nerve growth factor (NGF), a protein involved in the development of the nervous system and in diseases such as Alzheimer's disease. We found that the region preceding mature NGF has an independent function and is disordered and flexible.

The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain

Paoletti, Francesca;Gobbo, Francesco;Marchetti, Laura;Lamba, Doriano;GERVASIO, FRANCESCO LUIGI;Cattaneo, Antonino;Pastore, Annalisa
2019-01-01

Abstract

We describe here the function and structure of the precursor of nerve growth factor (NGF), a protein involved in the development of the nervous system and in diseases such as Alzheimer's disease. We found that the region preceding mature NGF has an independent function and is disordered and flexible.
growth factors; intrinsically unstructured proteins; NMR; paramagnetic relaxation enhancement; pro-peptides; structure; Structural Biology; Molecular Biology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11384/77916
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