We describe here the function and structure of the precursor of nerve growth factor (NGF), a protein involved in the development of the nervous system and in diseases such as Alzheimer's disease. We found that the region preceding mature NGF has an independent function and is disordered and flexible.
The Structure of the Pro-domain of Mouse proNGF in Contact with the NGF Domain
Paoletti, Francesca;Gobbo, Francesco;Marchetti, Laura;Lamba, Doriano;GERVASIO, FRANCESCO LUIGI;Cattaneo, Antonino;Pastore, Annalisa
2019
Abstract
We describe here the function and structure of the precursor of nerve growth factor (NGF), a protein involved in the development of the nervous system and in diseases such as Alzheimer's disease. We found that the region preceding mature NGF has an independent function and is disordered and flexible.File in questo prodotto:
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