Aim: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. Materials & methods: In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. Results & conclusion: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.

Cerium oxide nanoparticles: The regenerative redox machine in bioenergetic imbalance

Parlanti, Paola;
2017

Abstract

Aim: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. Materials & methods: In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. Results & conclusion: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.
2017
bioenergetic dysfunction; cerium oxide nanoparticles; mitochondria; Adult; Antioxidants; Cells, Cultured; Cerium; Drug Carriers; Energy Metabolism; Female; Fibroblasts; Humans; Male; Middle Aged; Mitochondria; Nanoparticles; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Bioengineering; Medicine (miscellaneous); Biomedical Engineering; Materials Science (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11384/83373
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