A possible turning point in drug delivery has been recently reached: the protein shell, which covers nanocarriers in vivo, can be used for targeting. Here, we show that nanoparticles can acquire a selective targeting capability with a protein corona adsorbed on the surface. We demonstrate that lipid particles made of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and DNA, upon interaction with human plasma components, spontaneously become coated with vitronectin that promotes efficient uptake in cancer cells expressing high levels of the vitronectin ανβ3 integrin receptor. © 2013 American Chemical Society.

Selective targeting capability acquired with a protein corona adsorbed on the surface of 1,2-dioleoyl-3-trimethylammonium propane/dna nanoparticles

Cardarelli, Francesco;Salomone, Fabrizio;Bardi, Giuseppe;
2013-01-01

Abstract

A possible turning point in drug delivery has been recently reached: the protein shell, which covers nanocarriers in vivo, can be used for targeting. Here, we show that nanoparticles can acquire a selective targeting capability with a protein corona adsorbed on the surface. We demonstrate that lipid particles made of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and DNA, upon interaction with human plasma components, spontaneously become coated with vitronectin that promotes efficient uptake in cancer cells expressing high levels of the vitronectin ανβ3 integrin receptor. © 2013 American Chemical Society.
Cationic lipids; Drug delivery; Nanoparticle; Protein corona; Targeting; Adult; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA; Fatty Acids, Monounsaturated; HEK293 Cells; Humans; Integrin alphaVbeta3; Liposomes; Nanoparticles; Particle Size; Protein Interaction Maps; Proteins; Quaternary Ammonium Compounds; Tandem Mass Spectrometry; Materials Science (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11384/73592
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